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  3. Therapy-induced APOBEC3A Drives Evolution of Persistent Cancer Cells

Therapy-induced APOBEC3A Drives Evolution of Persistent Cancer Cells

Introduction:

Published on August 23, 2023, in the prestigious journal Nature, a study led by Dr Kazuo Isozaki, alongside teams from renowned oncology research centers, explored the intriguing evolution of resistance mutations in non-small cell lung cancers (NSCLCs) treated with tyrosine kinase inhibitors (TKIs). The research in this paper focused on the following key questions:

  • How do non-small cell lung cancers (NSCLCs) develop resistance to tyrosine kinase inhibitors (TKIs)?
  • What role does APOBEC3A-induced mutagenesis play in the evolution of drug-resistant cancer cells?
  • Are there specific mutational signatures associated with APOBEC activity in TKI-treated tumors?
  • Can inhibiting APOBEC3A expression or activity prevent or delay the emergence of drug resistance in NSCLC?

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mRNA SequencingSwift & Express mRNA SequencingTotal RNA SequencingHuman Whole Genome SequencingWhole Exome Sequencing10x Single Cell Gene ExpressionIllumina PIP-seq Single Cell 3’ RNA SequencingSpatial Transcriptomics SequencingWhole Genome Bisulfite Sequencing (WGBS)Quantitative ProteomicsUntargeted MetabolomicsShotgun Metagenomics SequencingMetatranscriptome SequencingSequencing Only on Illumina SequencerSequencing Only on Ultima SequencerFull-Length Transcriptome SequencingChromatin Immunoprecipitation Sequencing (ChIP-seq)
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Novogene
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  • Genomics
    • Human Whole Genome Sequencing
    • Whole Exome Sequencing
    • Plant and Animal Whole Genome Sequencing
    • Plant and Animal De Novo Sequencing
    • Microbial Whole Genome Sequencing
    • Microbial De Novo Sequencing

    Metagenomics

    • Shotgun Metagenomics Sequencing
    • Amplicon Sequencing

    Transcriptomics

    • mRNA Sequencing
    • Swift & Express mRNA Sequencing New!
    • Full-Length Transcriptome Sequencing
    • Prokaryotic RNA Sequencing
    • Metatranscriptome Sequencing
    • Total RNA Sequencing
    • Small RNA Sequencing (sRNA‑seq)
    • Whole Transcriptome Sequencing

    Single Cell & Spatial Omics

    • 10x Single Cell Gene Expression
    • Illumina PIP-seq Single Cell 3’ RNA Sequencing New!
    • Spatial Transcriptomics Sequencing New!

    Epigenomics

    • Whole Genome Bisulfite Sequencing (WGBS)
    • Enzymatic Methylation Sequencing
    • Directed Methylation Sequencing (DM-Seq) New!
    • RNA Immunoprecipitation Sequencing (RIP-seq)
    • Chromatin Immunoprecipitation Sequencing (ChIP-seq)
    • Cleavage Under Targets & Tagmentation (CUT&Tag) New!
    • Assay for Transposase-Accessible Chromatin with Sequencing (ATAC-seq）
    • Reduced Representation Bisulfite Sequencing (RRBS)

    Proteomics

    • Quantitative Proteomics New!
    • PTM Proteomics New!
    • Olink Proteomics New!

    Metabolomics

    • Untargeted Metabolomics

    Premade Library

    • Sequencing Only on Illumina Sequencer
    • Sequencing Only on Ultima Sequencer
  • PromotionsPromotions
    • Platforms
    • Service & Support
    • Automated Delivery Platform (Falcon)
    • Bioinformatics Analysis Tool (NovoMagic)
    • Customer Service System (CSS)
    • Case Study
    • Blog
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    • Cancer Research
    • Immuno-oncology
    • Agrigenomics
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    • Plant and Animal Microbiome
    • Drug Discovery and Development
    • Rare and Complex Diseases
    • About Us
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    • News & Events
    • Careers
  • Contact UsContact Us
    • mRNA Sequencing
    • Illumina Lane Sequencing
  1. Home
  2. Resources
  3. Therapy-induced APOBEC3A Drives Evolution of Persistent Cancer Cells

Therapy-induced APOBEC3A Drives Evolution of Persistent Cancer Cells

Introduction:

Published on August 23, 2023, in the prestigious journal Nature, a study led by Dr Kazuo Isozaki, alongside teams from renowned oncology research centers, explored the intriguing evolution of resistance mutations in non-small cell lung cancers (NSCLCs) treated with tyrosine kinase inhibitors (TKIs). The research in this paper focused on the following key questions:

  • How do non-small cell lung cancers (NSCLCs) develop resistance to tyrosine kinase inhibitors (TKIs)?
  • What role does APOBEC3A-induced mutagenesis play in the evolution of drug-resistant cancer cells?
  • Are there specific mutational signatures associated with APOBEC activity in TKI-treated tumors?
  • Can inhibiting APOBEC3A expression or activity prevent or delay the emergence of drug resistance in NSCLC?

ServicesServices menu

CompanyCompany menu

Contact UsContact Us menu

Service SupportService Support menu

Services
mRNA SequencingSwift & Express mRNA SequencingTotal RNA SequencingHuman Whole Genome SequencingWhole Exome Sequencing10x Single Cell Gene ExpressionIllumina PIP-seq Single Cell 3’ RNA SequencingSpatial Transcriptomics SequencingWhole Genome Bisulfite Sequencing (WGBS)Quantitative ProteomicsUntargeted MetabolomicsShotgun Metagenomics SequencingMetatranscriptome SequencingSequencing Only on Illumina SequencerSequencing Only on Ultima SequencerFull-Length Transcriptome SequencingChromatin Immunoprecipitation Sequencing (ChIP-seq)
Company
About UsOur LocationsNews & EventsCareers
Contact Us
Contact Us
Service Support
Automated Delivery Platform (Falcon)Bioinformatics Analysis Tool (NovoMagic)Customer Service System (CSS)
LinkedInLinkedIn hoverYouTubeYouTube hoverXX hoverMetaMeta hoverInstagramInstagram hover
Copyright © 2026 Novogene Corporation Inc. All rights reserved. For Research Use Only.
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