Immuno-oncology focuses on understanding and developing therapies that harness the body’s immune system to recognize and eliminate cancer. Advances in this field have led to immunotherapeutics that have transformed cancer treatment. The immune system’s ability to mount such responses is governed by fundamental genetic programs and the cellular mechanisms they drive. In recent years, NGS technologies have been widely applied to investigate how tumours adapt to evade immune surveillance and to identify the molecular factors that influence responses to immunotherapy.
Whole-genome and whole-exome sequencing are widely used in immuno-oncology to assess tumour mutational burden (TMB). As an important biomarker, TMB helps estimate neoantigen load and supports cancer research and immunotherapy strategy development.
Genomics also helps identify neoantigens and other predictive mutations in oncogenes or tumour-suppressor genes. These insights can support treatment decision-making and improve patient stratification for immunotherapy studies.
Immuno-oncology focuses on understanding and developing therapies that harness the body’s immune system to recognize and eliminate cancer. Advances in this field have led to immunotherapeutics that have transformed cancer treatment. The immune system’s ability to mount such responses is governed by fundamental genetic programs and the cellular mechanisms they drive. In recent years, NGS technologies have been widely applied to investigate how tumours adapt to evade immune surveillance and to identify the molecular factors that influence responses to immunotherapy.
Whole-genome and whole-exome sequencing are widely used in immuno-oncology to assess tumour mutational burden (TMB). As an important biomarker, TMB helps estimate neoantigen load and supports cancer research and immunotherapy strategy development.
Genomics also helps identify neoantigens and other predictive mutations in oncogenes or tumour-suppressor genes. These insights can support treatment decision-making and improve patient stratification for immunotherapy studies.
